Determination of Allosteric Solvent Effects between Acetylcholinesterase and Mosquito Selective Carbamates: Implications for High Throughput Screening of Insecticides
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منابع مشابه
Selective inhibition of acetylcholinesterase 1 from disease-transmitting mosquitoes Design and development of new insecticides for vector control
iv Swedish summary v List of publications vi List of abbreviations viii 1. Introduction 1 1.1. Infectious diseases 1 1.2. Vector-borne infectious diseases 2 1.2.1. Malaria 2 1.2.2. Dengue 3 1.2.3. Other severe mosquito-borne diseases 4 1.3. Vectors 4 1.3.1. Mosquitoes as disease-vectors 5 1.3.2. Anopheles mosquitoes 5 1.3.3. Aedes mosquitoes 6 1.4. Vector control 7 1.4.1. Insecticid...
متن کاملMolecular cloning and characterization of the complete acetylcholinesterase gene (Ace1) from the mosquito Aedes aegypti with implications for comparative genome analysis.
Insensitive acetylcholinesterase (AChE) has been shown to be responsible for resistance to organophosphates and carbamates in a number of arthropod species. Some arthropod genomes contain a single Ace gene, while others including mosquitoes contain two genes, but only one confers insecticide resistance. Here we report the isolation of the full-length cDNA and characterization of the complete ge...
متن کاملIsolation and characterization of two novel organophosphate resistance mechanisms in Culex pipiens from Cyprus.
Two novel mechanisms of organophosphate resistance were isolated and characterized from a population of Culex pipiens L. from Cyprus. Two strains, one expressing the novel, highly active esterases A5 and B5 (strain A5B5-R), and one expressing insensitive acetylcholinesterase (strain Ace-R), were developed by single pair crosses and selection with temephos and propoxur, respectively. The A5B5-R ...
متن کاملTowards Mosquitocides for Prevention of Vector-Borne Infectious Diseases Discovery and Development of Acetylcholinesterase 1 Inhibitors
Diseases such as malaria and dengue impose great economic burdens and are a serious threat to public health, with young children being among the worst affected. These diseases are transmitted by mosquitoes, also called disease vectors, which are able to transmit both parasitic and viral infections. One of the most important strategies in the battle against mosquito-borne diseases is vector cont...
متن کاملA novel acetylcholinesterase gene in mosquitoes codes for the insecticide target and is non-homologous to the ace gene in Drosophila.
Acetylcholinesterase (AChE) is the target of two major insecticide families, organophosphates (OPs) and carbamates. AChE insensitivity is a frequent resistance mechanism in insects and responsible mutations in the ace gene were identified in two Diptera, Drosophila melanogaster and Musca domestica. However, for other insects, the ace gene cloned by homology with Drosophila does not code for the...
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تاریخ انتشار 2009